The effect of recurrent mutations on genetic diversity in a large population of varying size
Tuesday, 8 November, 2016 - 14:00
Résumé :
Recurrent mutations are a common phenomenon in population genetics. They may be at the origin of the fixation of a new genotype, if they give a phenotypic advantage to the carriers of the new mutation. In this paper, we are interested in the genetic signature left by a selective sweep induced by recurrent mutations at a given locus from an allele $A$ to an allele $a$, depending on the mutation frequency. We distinguish three possible scales for the mutation probability per reproductive event, which entail distinct genetic signatures. Besides, we study the hydrodynamic limit of the $A$- and $a$-population size dynamics when mutations are frequent, and find non trivial equilibria leading to several possible patterns of polymorphism.
Institution de l'orateur :
École Polytechnique
Thème de recherche :
Probabilités
Salle :
04